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Research Interests- Roles of cell cycle regulators (mainly the CDK inhibitors) in stem cell self-renewal.
- Distinct molecular mechanisms of leukemic stem cells versus normal hematopoietic stem cells.
- Stem cell protection in transplant recipients or under pathological conditions.
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Selected Publications- Shen H, Boyer M, Cheng T. (2008) "Flow cytometry-based cell cycle measurement of mouse hematopoietic stem and progenitor cells" Methods Mol Biol. 430:77-86. | Abstract
- Cheng T. (2008) "Toward 'SMART' stem cells" Gene Ther. 15:67-73. | Abstract
- Boyer MJ, Cheng T. (2008) "The CDK inhibitors: potential targets for therapeutic stem cell manipulations?" Gene Ther. 15:117-25. | Abstract
- Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT. (2006) "Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a" Nature 443:421-6. | Abstract
- Yuan Y, Yu H, Boyer MJ, Song X, Cao S, Shen H, Cheng T. (2006) "Hematopoietic stem cells are not the direct target of spontaneous leukemic transformation in p18(INK4C)-null reconstituted mice" Cancer Res. 66:343-51. | Abstract
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Grant Support- RO1 (HL70561): Stem cell efficiency regulated by CDK inhibitors.
- RO1 (EB001051): Quantitation of Cellular Protein Production in Real Time.
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Other
Links
University of Pittsburgh |
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Tao Cheng, M.D.
| Office:
5117 Center Ave., Room 2.42e |
| Lab:Pittsburgh, PA 15213 |
| Phone:412-623-3249 |
| Fax:
412-623-7778
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chengt@upmc.edu
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Academic Affiliations- Associate Professor,
Department of Radiation Oncology, Unviersity of Pittsburgh School of Medicine, Pittsburgh, PA, USA
- Director of Stem Cell Biology and Co-leader, Cancer Stem Cell Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
- Faculty Member, McGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA, Pittsburgh, PA, USA
- Member, Biochemistry and Molecular Genetics Graduate Program
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